SCHEMBL24909686

SCHEMBL24909686

N#Cc1cc(Br)c(O)c(-c2cnc(C(F)(F)F)nc2)c1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.50
ALB P02768 2/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
HTT P42858 1/20 0.37
GYS1 P13807 1/20 0.33
CYP11B2 P19099 1/20 0.31
XDH P47989 4/20 0.31
SLC22A12 Q96S37 4/20 0.31
GABRA1 P14867 1/20 0.30
GABRB1 P18505 1/20 0.30
GABRA2 P47869 1/20 0.30
GABRB2 P47870 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24909746 0.86 GYS1 (0.35) TTRALBMEN1KMT2AGYS1
SCHEMBL24909715 0.84 TTR (0.55) TTRALBMEN1KMT2AHTT
SCHEMBL24909743 0.82 TTR (0.53) TTRALBMEN1KMT2AHTT
SCHEMBL24909874 0.80 MEN1 (0.46) TTRALBMEN1KMT2AHTT
SCHEMBL24910010 0.79 TTR (0.56) TTRALBMEN1KMT2AHTT
SCHEMBL24909879 0.79 TTR (0.49) TTRALBMEN1KMT2AHTT
SCHEMBL24909846 0.79 MEN1 (0.45) TTRALBMEN1KMT2AGYS1
SCHEMBL24910027 0.78 KIF11 (0.51) TTRALBMEN1KMT2AXDH
SCHEMBL24909724 0.78 TTR (0.51) TTRALBMEN1KMT2AXDH
SCHEMBL24909370 0.75 TTR (0.60) TTRALBMEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230024283-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024283-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 TTR 4497/4885ALB 3928/4885MEN1 3221/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.