SCHEMBL24909775

SCHEMBL24909775

COc1cc(-c2cc(C#N)cc(C(F)(F)F)c2O)ccc1F

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
AR P10275 8/20 0.45
PGR P06401 4/20 0.45
KIF11 P52732 1/20 0.41
KDM4E B2RXH2 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
SLC22A12 Q96S37 3/20 0.39
XDH P47989 2/20 0.38
MAPT P10636 1/20 0.37
ATM Q13315 1/20 0.37
ALDH1A1 P00352 1/20 0.37
EGFR P00533 1/20 0.36
ADORA2A P29274 1/20 0.36
ADORA1 P30542 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24909748 0.90 AR (0.45) ARPGRKIF11SLC22A12XDH
SCHEMBL24909689 0.82 MEN1 (0.45) ARPGRKDM4ETDP1SLC22A12
SCHEMBL24909739 0.81 KIF11 (0.43) ARPGRKIF11SLC22A12XDH
SCHEMBL24909933 0.81 LRRK2 (0.41) ARPGRKDM4ETDP1MAPT
SCHEMBL24909876 0.80 PDGFRB (0.41) ARPGRSLC22A12XDHMAPT
SCHEMBL24909891 0.79 AR (0.43) ARPGRKDM4ESLC22A12XDH
SCHEMBL24910064 0.78 RPS6KA3 (0.44) ARPGR
SCHEMBL24909729 0.78 KDM4E (0.43) ARPGRKIF11KDM4ESLC22A12
SCHEMBL24909754 0.78 AR (0.40) ARPGRKIF11KDM4EMAPT
SCHEMBL24910011 0.77 AR (0.43) ARPGRKIF11KDM4ESLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230024283-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024283-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 AR 3997/4885PGR 4667/4885KIF11 2192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.