Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13745049 | 0.83 | GLA (0.50) | GLASMN1; SMN2CYP1A2MAPK1LMNA | |
| SCHEMBL28656724 | 0.81 | SLC6A9 (0.45) | KDM4EGPR183MEN1KMT2AALDH1A1 | |
| SCHEMBL22215016 | 0.81 | SLC6A9 (0.45) | KDM4EGPR183MEN1KMT2AALDH1A1 | |
| SCHEMBL20822500 | 0.81 | SLC6A9 (0.45) | KDM4EGPR183MEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL2949425 | 0.81 | GLA (0.53) | GLASMN1; SMN2CYP1A2MAPK1LMNA | |
| Propane SCHEMBL1995071 | 0.80 | GLA (0.59) | GLASMN1; SMN2CYP1A2MAPK1LMNA | |
| SCHEMBL13515770 | 0.80 | GLA (0.47) | GLASMN1; SMN2CYP1A2MAPK1KMT2A | |
| Alcohol SCHEMBL5801058 | 0.78 | GLA (0.57) | GLASMN1; SMN2CYP1A2MAPK1MEN1 | |
| Alcohol SCHEMBL28379053 | 0.78 | GLA (0.57) | GLASMN1; SMN2CYP1A2MAPK1MEN1 | |
| SCHEMBL1069692 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601297-B9 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC (US) | 2023-05-24 | — | — | EP | disclosed |