Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | PSEN1 | P49768 | 1/20 | 1.00 |
| ▸ | PSEN2 | P49810 | 1/20 | 1.00 |
| ▸ | APH1B | Q8WW43 | 1/20 | 1.00 |
| ▸ | NCSTN | Q92542 | 1/20 | 1.00 |
| ▸ | APH1A | Q96BI3 | 1/20 | 1.00 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 11/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 11/20 | 0.53 |
| ▸ | APP | P05067 | 4/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847511 | 1.00 | KCNH2 (1.00) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2846664 | 1.00 | KCNH2 (1.00) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2844065 | 0.90 | KCNH2 (0.82) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2841532 | 0.90 | KCNH2 (0.81) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2853878 | 0.90 | KCNH2 (0.81) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2878421 | 0.87 | KCNH2 (0.77) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2849624 | 0.87 | PSEN1 (0.77) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2846217 | 0.87 | PSEN1 (0.77) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2846415 | 0.85 | KCNH2 (0.73) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2872891 | 0.85 | KCNH2 (0.73) | KCNH2PTGS1PTGS2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230029372-A1 | THERAPEUTIC COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF DIASTOLIC DYSFUNCTION | Ambetex Pty Ltd (AU) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230029372-A1 | THERAPEUTIC COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF DIASTOLIC DYSFUNCTION | TNNI3, TNNT2, TNNC1 | KCNH2 2136/4885PTGS1 701/4885PTGS2 1063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.