Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491393 | 1.00 | CYP1A2 (1.00) | CYP1A2KMT2ASMN1; SMN2POLBMAOA | |
| SCHEMBL19449690 | 0.88 | CYP1A2 (0.78) | CYP1A2KMT2ASMN1; SMN2POLBMAOA | |
| SCHEMBL17560844 | 0.88 | CYP1A2 (0.78) | CYP1A2KMT2ASMN1; SMN2POLBMAOA | |
| SCHEMBL29659678 | 0.86 | CYP1A2 (0.76) | CYP1A2KMT2ASMN1; SMN2POLBMAOA | |
| SCHEMBL17560740 | 0.85 | CYP1A2 (0.73) | CYP1A2KMT2ASMN1; SMN2POLBMAOA | |
| SCHEMBL17560738 | 0.85 | CYP1A2 (0.73) | CYP1A2KMT2ASMN1; SMN2POLBMAOA | |
| SCHEMBL28632043 | 0.85 | CYP1A2 (0.73) | CYP1A2KMT2ASMN1; SMN2POLBMAOA | |
| SCHEMBL12735427 | 0.83 | MAPT (0.82) | CYP1A2KMT2ASMN1; SMN2POLBRAB9A | |
| SCHEMBL6444113 | 0.83 | CYP1A2 (0.71) | CYP1A2KMT2ASMN1; SMN2POLBMAOA | |
| SCHEMBL6444110 | 0.83 | CYP1A2 (0.71) | CYP1A2KMT2ASMN1; SMN2POLBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379557-B1 | AMINO PYRAZOLE COMPOUND | LILLY CO ELI (US) | 2012-10-31 | — | — | EP | disclosed |
| EP-2379557-A1 | AMINO PYRAZOLE COMPOUND | Eli Lilly and Company (US) | 2011-10-26 | — | — | EP | disclosed |
| US-7897600-B2 | Amino pyrazole compound | ELI LILLY AND COMPANY (US) | 2011-03-01 | — | — | US | disclosed |
| US-20100286139-A1 | AMINO PYRAZOLE COMPOUND | ELI LILLY AND COMPANY (US) | 2010-11-11 | — | — | US | disclosed |
| WO-2010074947-A1 | AMINO PYRAZOLE COMPOUND | ELI LILLY AND COMPANY (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20100152181-A1 | AMINO PYRAZOLE COMPOUND | ELI LILLY AND COMPANY (US) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286139-A1 | AMINO PYRAZOLE COMPOUND | MCL1, MYC, PML | CYP1A2 2619/4885KMT2A 237/4885SMN1; SMN2 2537/4885 |
| US-20100152181-A1 | AMINO PYRAZOLE COMPOUND | MCL1, MYC, PML | CYP1A2 2619/4885KMT2A 237/4885SMN1; SMN2 2537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.