SCHEMBL24914042

SCHEMBL24914042

COc1ccc2c(c1)CCN(C(=O)c1c(O)cc(O)cc1OCc1ccccc1)C2

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
ESR1 P03372 1/20 0.47
ESR2 Q92731 1/20 0.47
GPR183 P32249 1/20 0.47
KMT2A Q03164 3/20 0.46
NPC1 O15118 2/20 0.46
HRH3 Q9Y5N1 1/20 0.46
CHRNA7 P36544 2/20 0.44
TAAR1 Q96RJ0 1/20 0.44
RAB9A P51151 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
ABHD6 Q9BV23 1/20 0.44
KDM4E B2RXH2 1/20 0.44
ALOX15 P16050 1/20 0.44
HSD17B10 Q99714 1/20 0.44
TMEM97 Q5BJF2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30789170 1.00 CA1 (0.52) CA1CA2CA7CA9CA14
SCHEMBL24914043 0.96 CA1 (0.48) CA1CA2CA7CA9CA14
SCHEMBL31062032 0.96 CA1 (0.48) CA1CA2CA7CA9CA14
SCHEMBL30368448 0.92 HDAC8 (0.44) CA1CA2CA7CA9CA14
SCHEMBL25668992 0.92 HDAC8 (0.44) CA1CA2CA7CA9CA14
SCHEMBL31013684 0.89 CA1 (0.48) CA1CA2CA7CA9CA14
SCHEMBL25669032 0.88 SPR (0.54) CA1CA2CA7CA9CA14
SCHEMBL30156656 0.88 SPR (0.54) CA1CA2CA7CA9CA14
SCHEMBL31013763 0.86 CA1 (0.44) CA1CA2CA7CA9CA14
SCHEMBL24914225 0.85 QRFPR (0.49) ESR1GPR183KMT2ANPC1CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117693507-A Inhibitor compounds 奈奥芬莱有限公司 2024-03-12 CN claimed
CN-117693507-A Inhibitor compounds 奈奥芬莱有限公司 2024-03-12 CN disclosed
WO-2023002165-A1 INHIBITOR COMPOUNDS Neophore Limited (GB) 2023-01-26 WO disclosed