Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 7/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24914400 | 0.94 | CLPP (0.61) | CLPPPTGDR2ENPP2CYP3A4EP300 | |
| SCHEMBL24914395 | 0.84 | CLPP (0.55) | CLPPENPP2DDB1CRBNACHE | |
| SCHEMBL28984498 | 0.83 | ENPP2 (0.55) | CLPPPTGDR2ENPP2EP300CREBBP | |
| SCHEMBL24914406 | 0.83 | CLPP (0.60) | CLPPENPP2DDB1CRBN | |
| SCHEMBL24914771 | 0.83 | CLPP (0.60) | CLPPENPP2DDB1CRBN | |
| SCHEMBL30130042 | 0.83 | CLPP (0.53) | CLPPENPP2CYP3A4 | |
| SCHEMBL24914800 | 0.82 | CLPP (0.52) | CLPPPTGDR2ENPP2DDB1CRBN | |
| SCHEMBL24914705 | 0.82 | CLPP (0.52) | CLPPPTGDR2ENPP2DDB1CRBN | |
| SCHEMBL24914505 | 0.82 | CLPP (0.59) | CLPPENPP2DDB1CRBN | |
| SCHEMBL24915121 | 0.82 | CLPP (0.59) | CLPPENPP2DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023284807-A1 | COMPOUND CONTAINING TETRAHYDRONAPHTHYRIDONE OR TETRAHYDROPYRIDOPYRIMIDINONE SKELETON, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2023-01-19 | — | — | WO | disclosed |