SCHEMBL24914810

SCHEMBL24914810

N#Cc1cccc(CN2CCc3c(c(=O)n(Cc4ccc(Cl)cc4)c4cncn34)C2)c1

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CLPP Q16740 20/20 0.71
CYP3A4 P08684 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30130243 1.00 CLPP (0.71) CLPPCYP3A4
SCHEMBL24914573 0.90 CLPP (0.58) CLPPCYP3A4
SCHEMBL30130096 0.90 CLPP (0.58) CLPPCYP3A4
SCHEMBL24914433 0.89 CLPP (0.68) CLPPCYP3A4
SCHEMBL30130098 0.89 CLPP (0.68) CLPPCYP3A4
SCHEMBL30183854 0.84 CLPP (0.55) CLPPCYP3A4
SCHEMBL24914452 0.84 CLPP (0.70) CLPPCYP3A4
SCHEMBL30130176 0.83 CLPP (1.00) CLPPCYP3A4
SCHEMBL24914434 0.83 CLPP (1.00) CLPPCYP3A4
SCHEMBL31547384 0.81 CLPP (1.00) CLPPCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023284807-A1 COMPOUND CONTAINING TETRAHYDRONAPHTHYRIDONE OR TETRAHYDROPYRIDOPYRIMIDINONE SKELETON, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF 中国药科大学 2023-01-19 WO disclosed
CN-115611896-A Compound containing tetralone or tetrahydropyridopyrimidone skeleton and preparation method and pharmaceutical application thereof 中国药科大学 2023-01-17 CN disclosed