Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | CLPP | Q16740 | 5/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 8/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30130104 | 1.00 | MAPT (0.67) | MAPTTHRBCLPPENPP2DRD2 | |
| SCHEMBL24914726 | 0.91 | MAPT (0.64) | MAPTCLPPENPP2 | |
| SCHEMBL30130057 | 0.91 | MAPT (0.64) | MAPTCLPPENPP2 | |
| SCHEMBL30130063 | 0.91 | DRD2 (0.57) | MAPTTHRBCLPPDRD2DRD4 | |
| SCHEMBL24914661 | 0.91 | DRD2 (0.57) | MAPTTHRBCLPPDRD2DRD4 | |
| SCHEMBL24914822 | 0.91 | MAPT (0.56) | MAPTCLPPENPP2 | |
| SCHEMBL30130032 | 0.91 | MAPT (0.56) | MAPTCLPPENPP2 | |
| SCHEMBL24914465 | 0.91 | MAPT (0.56) | MAPTCLPPENPP2 | |
| SCHEMBL24915108 | 0.90 | CLPP (0.61) | MAPTCLPPENPP2 | |
| SCHEMBL24914768 | 0.90 | CLPP (0.61) | MAPTTHRBCLPPENPP2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023284807-A1 | COMPOUND CONTAINING TETRAHYDRONAPHTHYRIDONE OR TETRAHYDROPYRIDOPYRIMIDINONE SKELETON, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2023-01-19 | — | — | WO | disclosed |