SCHEMBL24914857

SCHEMBL24914857

C=CCN(C(=O)c1ccc(C#N)nc1)c1cccc(C(=O)Nc2c(I)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)c1F

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
BRAF P15056 1/20 0.33
FAAH O00519 1/20 0.31
SCN10A Q9Y5Y9 1/20 0.31
KCNQ3 O43525 1/20 0.31
KCNQ2 O43526 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24914495 0.91 PTGES (0.31)
SCHEMBL24914632 0.90 PTGES (0.30)
SCHEMBL24914869 0.90 BRAF (0.32) BRAFFAAHSCN10AKCNQ3KCNQ2
SCHEMBL24914954 0.89 RXFP1 (0.37)
SCHEMBL23053028 0.88 FAAH (0.33) BRAFFAAHSCN10AKCNQ3KCNQ2
SCHEMBL20846765 0.87 BRAF (0.38) BRAFFAAHSCN10AKCNQ3KCNQ2
SCHEMBL24914763 0.86 KCNK3 (0.35)
SCHEMBL25085597 0.85 AR (0.35)
SCHEMBL23059628 0.84 GPBAR1 (0.34) BRAF
SCHEMBL25085560 0.84 GPBAR1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023284645-A1 AMIDE COMPOUND AND USE THEREOF 沈阳化工大学 2023-01-19 WO disclosed