SCHEMBL2491527

SCHEMBL2491527

O=C(O)c1c[nH]c(=S)[nH]c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM3B Q7LBC6 1/20 1.00
▸ KDM4E B2RXH2 6/20 0.46
▸ KMT2A Q03164 2/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42
▸ GAA P10253 3/20 0.41
▸ HPGD P15428 2/20 0.41
▸ HSD17B10 Q99714 2/20 0.41
▸ DYRK1A Q13627 1/20 0.41
▸ NAPRT Q6XQN6 1/20 0.39
▸ CYP2C19 P33261 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ KDM6B O15054 1/20 0.37
▸ KDM4A O75164 1/20 0.37
▸ KDM4D Q6B0I6 1/20 0.37
▸ HIF1AN Q9NWT6 1/20 0.37
▸ KDM2A Q9Y2K7 1/20 0.37
▸ CSNK2A1 P68400 1/20 0.37
▸ PIM3 Q86V86 1/20 0.37
▸ CLK4 Q9HAZ1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1210851 0.82 KDM3B (0.69) KDM3BKDM4EKMT2ATDP1GAA
SCHEMBL21246609 0.79 KDM3B (0.65) KDM3BKDM4EKMT2ATDP1
SCHEMBL127493 0.78 KDM3B (0.64) KDM3BKDM4EGAAHPGDHSD17B10
SCHEMBL9443874 0.78 KDM3B (0.60) KDM3BKDM4EKMT2ATDP1GAA
SCHEMBL10001205 0.77 KDM3B (0.62) KDM3BKDM4EKMT2ATDP1GAA
SCHEMBL12872720 0.77 KDM3B (0.62) KDM3BKDM4EKMT2ATDP1GAA
Hydrochloric Acid SCHEMBL11439523 0.77 KDM3B (0.62) KDM3BKDM4EGAAHPGDHSD17B10
Water SCHEMBL4487821 0.77 KDM3B (0.62) KDM3BKDM4EGAAHPGDHSD17B10
SCHEMBL1810204 0.73 KMT2A (0.61) KDM3BKDM4EKMT2ATDP1GAA
Dimethylamine SCHEMBL1524840 0.72 KDM3B (0.56) KDM3BKDM4EKMT2AGAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116462633-A Modified opening agent and preparation method thereof, and easily-printed modified biodegradable material and preparation method thereof 万华化学(宁波)有限公司 2023-07-21 — — CN claimed
EP-1206551-B2 ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOSIDES PASTEUR INSTITUT (FR) 2011-10-26 — — EP claimed
EP-1625234-B1 BIOSYNTHETIC LABELING AND SEPARATION OF RNA UNIV LELAND STANFORD JUNIOR (US) 2009-08-19 — — EP claimed
EP-1206551-B1 ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOSIDES PASTEUR INSTITUT (FR) 2009-05-13 — — EP claimed
US-20080280329-A1 Enzymatic synthesis of deoxyribonucleosides TISCHER WILHELM 2008-11-13 — — US claimed
US-7229797-B1 Enzymatic synthesis of deoxyribonucleosides INSTITUT PASTEUR (FR) 2007-06-12 — — US claimed
EP-1206551-A2 ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOSIDES Roche Diagnostics GmbH (DE) 2002-05-22 — — EP claimed
WO-2001014566-A2 ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOSIDES ROCHE DIAGNOSTICS GMBH (DE) 2001-03-01 — — WO claimed
JP-10001473-A — — None — — JP disclosed
US-12054768-B2 Methods for detecting agglutination and compositions for use in practicing the same THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-08-06 — — US disclosed
US-20230293524-A1 OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY SPIRAL THERAPEUTICS INC. 2023-09-21 — — US disclosed
US-20230293524-A1 OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY SPIRAL THERAPEUTICS INC. 2023-09-21 — — US disclosed
US-20230293524-A1 OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY SPIRAL THERAPEUTICS INC. 2023-09-21 — — US disclosed
CN-116462633-A Modified opening agent and preparation method thereof, and easily-printed modified biodegradable material and preparation method thereof 万华化学(宁波)有限公司 2023-07-21 — — CN disclosed
WO-1992020816-A1 DETERMINATION OF PRODRUGS METABOLIZABLE BY THE LIVER AND THERAPEUTIC USE THEREOF YALE UNIVERSITY (US) 1992-11-26 — — WO disclosed
EP-0504279-A1 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES. CHEMGEN CORP (US) 1992-09-23 — — EP disclosed
WO-1991009130-A1 FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES CHEMGEN CORPORATION (US) 1991-06-27 — — WO disclosed
EP-0280128-A2 Process for the preparation of 1-(3-azido-2,3-dideoxy-beta-D-erythro-pentofuranoxyl) pyrimidines, and intermediates BAYER AG (DE) 1988-08-31 — — EP disclosed
EP-0263740-A1 Coupling conjugates between RNA or DNA sequences and a protein, method for their preparation and their biological use CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1988-04-13 — — EP disclosed
US-3993661-A Quinone methide photograhpic reagent precursors POLAROID CORPORATION (US) 1976-11-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230293524-A1 OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY OTC, SLC26A4, OAT KDM3B 3596/4885KDM4E 4100/4885KMT2A 4008/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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