Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.67 |
| ▸ | MMP1 | P03956 | 2/20 | 0.66 |
| ▸ | MMP9 | P14780 | 2/20 | 0.66 |
| ▸ | MMP8 | P22894 | 2/20 | 0.66 |
| ▸ | MMP3 | P08254 | 1/20 | 0.66 |
| ▸ | MMP2 | P08253 | 2/20 | 0.63 |
| ▸ | ECE1 | P42892 | 11/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | APAF1 | O14727 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23380923 | 0.92 | ECE1 (0.69) | ACEMMP1MMP9MMP8MMP3 | |
| SCHEMBL21929719 | 0.90 | MMP9 (0.64) | ACEMMP1MMP9MMP8MMP3 | |
| SCHEMBL23417971 | 0.85 | ECE1 (0.64) | ACEMMP1MMP9MMP8MMP3 | |
| SCHEMBL23875110 | 0.85 | ECE1 (0.64) | ACEMMP1MMP9MMP8MMP3 | |
| SCHEMBL13176572 | 0.83 | TACR1 (0.67) | ACEMMP9MMP8ALOX15KDM4E | |
| SCHEMBL5747459 | 0.83 | TACR1 (0.67) | ACEMMP9MMP8ALOX15KDM4E | |
| SCHEMBL16301507 | 0.83 | ECE1 (0.66) | ACEMMP1MMP9MMP8MMP3 | |
| SCHEMBL21955437 | 0.83 | ACE (0.72) | ACEMMP1MMP9MMP8MMP3 | |
| SCHEMBL14011116 | 0.83 | MMP9 (0.64) | ACEMMP1MMP9MMP8MMP3 | |
| SCHEMBL26169713 | 0.83 | ECE1 (0.66) | ACEMMP1MMP9MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102507-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-08 | — | — | WO | disclosed |
| WO-2023004240-A1 | MACROCYLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-01-26 | — | — | WO | disclosed |