Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490382 | 0.93 | KDM4E (0.43) | MCL1PIK3CDKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4037851 | 0.93 | PTGER1 (0.47) | MCL1PTGER1MRGPRX4P4HTMNOTUM | |
| SCHEMBL912923 | 0.92 | NOTUM (0.44) | MCL1PIK3CDKDM4EALDH1A1CYP1A2 | |
| SCHEMBL544584 | 0.86 | NOTUM (0.51) | MCL1KDM4EPTGER1MAPTMRGPRX4 | |
| SCHEMBL4038711 | 0.86 | FFAR1 (0.42) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4041123 | 0.85 | MCL1 (0.46) | MCL1KDM4EPTGER1MAPTMRGPRX4 | |
| SCHEMBL2488886 | 0.85 | CSNK2A2 (0.39) | MCL1KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2492927 | 0.85 | KMO (0.44) | MCL1KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL914548 | 0.85 | NOTUM (0.45) | PIK3CDKDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2492027 | 0.84 | CSNK2A2 (0.41) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238110-B1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI SA (FR) | 2011-10-26 | — | — | EP | disclosed |
| EP-2238110-A1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009115665-A1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI-AVENTIS (FR) | 2009-09-24 | — | — | WO | disclosed |