Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913698 | 0.91 | NOTUM (0.45) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4036485 | 0.89 | PTGER1 (0.47) | SMN1; SMN2NPC1RAB9AMRGPRX4HPGD | |
| SCHEMBL2490382 | 0.86 | KDM4E (0.43) | KMOKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2489148 | 0.86 | PPARD (0.43) | KMOKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4038711 | 0.85 | FFAR1 (0.42) | KMOKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2491639 | 0.85 | MCL1 (0.43) | KMOKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2492027 | 0.85 | CSNK2A2 (0.41) | KMOKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2488886 | 0.84 | CSNK2A2 (0.39) | KMOKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2490092 | 0.83 | UCHL1 (0.40) | KMOKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL544534 | 0.82 | NOTUM (0.56) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238110-B1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI SA (FR) | 2011-10-26 | — | — | EP | disclosed |
| EP-2238110-A1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009115665-A1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI-AVENTIS (FR) | 2009-09-24 | — | — | WO | disclosed |