SCHEMBL24916641

SCHEMBL24916641

COc1ccc(-c2ccccc2)cc1N(NC(=O)OC(C)C)C(=O)OC(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACLY P53396 5/20 0.41
PDCD1 Q15116 1/20 0.41
CD274 Q9NZQ7 1/20 0.41
MCHR1 Q99705 3/20 0.39
HTR2C P28335 1/20 0.39
NR1H4 Q96RI1 1/20 0.39
MEN1 O00255 1/20 0.38
POLB P06746 1/20 0.38
KMT2A Q03164 1/20 0.38
ABCC1 P33527 1/20 0.38
KDM4E B2RXH2 1/20 0.38
APAF1 O14727 1/20 0.38
RECQL P46063 1/20 0.38
CASP6 P55212 1/20 0.38
CACNA1B Q00975 1/20 0.38
APBA1 Q02410 1/20 0.38
MCL1 Q07820 1/20 0.38
CASP8 Q14790 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
HDAC1 Q13547 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24916644 0.86 PDCD1 (0.43) PDCD1CD274KDM4EMCL1HDAC1
SCHEMBL7516594 0.83 MCHR1 (0.41) ACLYPDCD1CD274MCHR1HTR2C
SCHEMBL7508281 0.83 NR1H4 (0.41) ACLYPDCD1CD274MCHR1HTR2C
SCHEMBL7514062 0.83 ACLY (0.41) ACLYPDCD1CD274MCHR1HTR2C
SCHEMBL6826033 0.74 ACLY (0.45) ACLYMCHR1HTR2CMEN1POLB
SCHEMBL28636145 0.74 SMN1; SMN2 (0.47) PDCD1CD274MEN1KMT2ASMN1; SMN2
Bifenazate SCHEMBL26414 0.73 KMT2A (0.49) ACLYPDCD1CD274MEN1POLB
Bifenazate SCHEMBL29370770 0.73 KMT2A (0.49) ACLYPDCD1CD274MEN1POLB
Bifenazate SCHEMBL28174080 0.72 KMT2A (0.48) ACLYPDCD1CD274MEN1POLB
SCHEMBL6239958 0.69 ACLY (0.46) ACLYNR1H4MEN1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023000616-A1 METHOD FOR PREPARING BIFENAZATE 帕潘纳(北京)科技有限公司 2023-01-26 WO disclosed