Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 9/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.42 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.42 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2237940 | 0.92 | HPGD (0.50) | GRIK1GRIK2GRIA1GRIA2GRIA4 | |
| SCHEMBL2237937 | 0.92 | HPGD (0.50) | GRIK1GRIK2GRIA1GRIA2GRIA4 | |
| SCHEMBL2237095 | 0.91 | ALDH1A1 (0.53) | GRIK1GRIK2CYP3A4HPGDCYP2C19 | |
| SCHEMBL2237105 | 0.91 | ALDH1A1 (0.53) | GRIK1GRIK2CYP3A4HPGDCYP2C19 | |
| SCHEMBL13584985 | 0.88 | GRIK1 (0.37) | GRIK1GRIK2GRIA1GRIA2GRIA4 | |
| SCHEMBL13584983 | 0.88 | GRIK1 (0.37) | GRIK1GRIK2GRIA1GRIA2GRIA4 | |
| SCHEMBL10132089 | 0.84 | LMNA (0.44) | CYP3A4HPGDCYP2C19RAB9AALDH1A1 | |
| SCHEMBL31370247 | 0.83 | GRIK1 (0.39) | GRIK1GRIK2GRIA1GRIA2GRIA4 | |
| SCHEMBL1768527 | 0.81 | SMN1; SMN2 (0.50) | GRIK1GRIK2GRIA1GRIA2GRIA4 | |
| SCHEMBL1768530 | 0.81 | SMN1; SMN2 (0.50) | GRIK1GRIK2GRIA1GRIA2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4653840-B2 | — | — | 2011-03-16 | — | — | JP | claimed |
| JP-2009520682-A | — | — | 2009-05-28 | — | — | JP | claimed |
| EP-1963362-A1 | METASTIN DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-09-03 | — | — | EP | claimed |
| WO-2007072997-A1 | METASTIN DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-06-28 | — | — | WO | claimed |
| EP-2379053-A1 | PROPHYLACTIC/THERAPEUTIC AGENT FOR CANCER | Takeda Pharmaceutical Company Limited (JP) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010076896-A1 | PROPHYLACTIC/THERAPEUTIC AGENT FOR CANCER | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-07-08 | — | — | WO | disclosed |
| EP-1963362-A1 | METASTIN DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007072997-A1 | METASTIN DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-06-28 | — | — | WO | disclosed |