Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | LPL | P06858 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14361867 | 0.90 | TP53 (0.59) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL31409202 | 0.88 | TSHR (0.48) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL7919067 | 0.88 | ESR1 (0.53) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL14018688 | 0.84 | SLC2A1 (0.55) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL19324885 | 0.84 | SLC2A1 (0.55) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL19324608 | 0.82 | GRK6 (0.49) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL36295 | 0.80 | TP53 (0.67) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL500563 | 0.80 | TSHR (0.56) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL139408 | 0.80 | L3MBTL1 (0.56) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL19622539 | 0.79 | L3MBTL1 (0.41) | TSHRMAPK1ATMTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7232634-B2 | Charge generating layer and a charge transport layer with bulky organic groups to prevent recrystallization of the charge transport molecule and shield the nitrogen from molecular attack; oxidation reisitance, wear resistance | XEROX CORPORATION (US) | 2007-06-19 | — | — | US | claimed |
| EP-2380567-B1 | MELANIN PRODUCTION INHIBITOR | POLA CHEM IND INC (JP) | 2019-01-16 | — | — | EP | disclosed |
| EP-3009123-A1 | MELANIN PRODUCTION INHIBITOR | Pola Chemical Industries Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |
| US-20150328107-A1 | MELANIN PRODUCTION INHIBITOR | POLA CHEMICAL INDUSTRIES INC. (JP) | 2015-11-19 | — | — | US | disclosed |
| EP-2845587-A2 | Melanin production inhibitor | Pola Chemical Industries Inc. (JP) | 2015-03-11 | — | — | EP | disclosed |
| US-20140363389-A1 | MELANIN PRODUCTION INHIBITOR | POLA CHEMICAL INDUSTRIES INC. (JP) | 2014-12-11 | — | — | US | disclosed |
| US-8846012-B2 | Melanin production inhibitor | POLA CHEMICAL INDUSTRIES INC. (JP) | 2014-09-30 | — | — | US | disclosed |
| EP-2380567-A1 | MELANIN PRODUCTION INHIBITOR | Pola Chemical Industries Inc. (JP) | 2011-10-26 | — | — | EP | disclosed |
| US-20110243865-A1 | MELANIN PRODUCTION INHIBITOR | POLA CHEMICAL INDUSTRIES INC. (JP) | 2011-10-06 | — | — | US | disclosed |
| US-7232634-B2 | Charge generating layer and a charge transport layer with bulky organic groups to prevent recrystallization of the charge transport molecule and shield the nitrogen from molecular attack; oxidation reisitance, wear resistance | XEROX CORPORATION (US) | 2007-06-19 | — | — | US | disclosed |
| US-20060068309-A1 | Imaging member | XEROX CORPORATION | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110243865-A1 | MELANIN PRODUCTION INHIBITOR | TYR, F12, TH | TSHR 100/4885MAPK1 172/4885ATM 2913/4885 |
| US-20150328107-A1 | MELANIN PRODUCTION INHIBITOR | TYR, MC1R, F12 | TSHR 75/4885MAPK1 221/4885ATM 2976/4885 |
| US-20140363389-A1 | MELANIN PRODUCTION INHIBITOR | TYR, F12, MC1R | TSHR 68/4885MAPK1 194/4885ATM 2836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.