Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.34 |
| ▸ | FDPS | P14324 | 3/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20869954 | 1.00 | TSHR (0.56) | TSHRLMNADNM1THRBOPRM1 | |
| SCHEMBL18723240 | 0.93 | TSHR (0.59) | TSHRLMNADNM1THRBOPRM1 | |
| SCHEMBL18723189 | 0.93 | TSHR (0.59) | TSHRLMNADNM1THRBOPRM1 | |
| SCHEMBL18723237 | 0.93 | TSHR (0.59) | TSHRLMNADNM1THRBOPRM1 | |
| SCHEMBL18638734 | 0.91 | TSHR (0.56) | TSHRLMNADNM1THRBALDH1A1 | |
| SCHEMBL20053307 | 0.91 | TSHR (0.62) | TSHRLMNADNM1THRBOPRM1 | |
| SCHEMBL7761911 | 0.89 | TSHR (0.54) | TSHRLMNADNM1THRBOPRM1 | |
| SCHEMBL7765607 | 0.89 | TSHR (0.54) | TSHRLMNADNM1THRBOPRM1 | |
| SCHEMBL17970381 | 0.88 | TSHR (0.59) | TSHRLMNADNM1ALDH1A1 | |
| SCHEMBL17935724 | 0.85 | TSHR (0.40) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | PIK3CA, PIK3CG, PIK3CD | TSHR 3567/4885LMNA 4493/4885DNM1 2006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.