Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21416476 | 1.00 | MAPT (0.44) | MAPTALDH1A1POLBNAAAGPR84 | |
| SCHEMBL19223903 | 1.00 | MAPT (0.44) | MAPTALDH1A1POLBNAAAGPR84 | |
| SCHEMBL28143791 | 1.00 | MAPT (0.44) | MAPTALDH1A1POLBNAAAGPR84 | |
| SCHEMBL27485167 | 1.00 | MAPT (0.44) | MAPTALDH1A1POLBNAAAGPR84 | |
| Hydrochloric Acid SCHEMBL572560 | 0.98 | ALDH1A1 (0.42) | MAPTALDH1A1POLBNAAAGPR84 | |
| Hydrochloric Acid SCHEMBL16774421 | 0.98 | ALDH1A1 (0.42) | MAPTALDH1A1POLBNAAAGPR84 | |
| Fluoride SCHEMBL29252743 | 0.98 | MAPT (0.42) | MAPTALDH1A1POLBNAAAGPR84 | |
| Hydrochloric Acid SCHEMBL29252918 | 0.98 | ALDH1A1 (0.42) | MAPTALDH1A1POLBNAAAGPR84 | |
| Hydrochloric Acid SCHEMBL27371328 | 0.98 | ALDH1A1 (0.42) | MAPTALDH1A1POLBNAAAGPR84 | |
| SCHEMBL9663065 | 0.98 | MAPT (0.45) | MAPTALDH1A1POLBNAAAGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | PIK3CA, PIK3CG, PIK3CD | MAPT 3674/4885ALDH1A1 3899/4885POLB 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.