SCHEMBL24920380

SCHEMBL24920380

CN1CCc2cnc(C(N)=O)nc2C1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
MAP4K1 Q92918 6/20 0.35
MAOA P21397 2/20 0.35
MAOB P27338 2/20 0.35
PARP1 P09874 4/20 0.35
PARP2 Q9UGN5 3/20 0.35
SYK P43405 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
GLA P06280 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
KMT2A Q03164 1/20 0.35
CCNA2 P20248 1/20 0.34
CDK2 P24941 1/20 0.34
CCNA1 P78396 1/20 0.34
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24922026 0.87 MAOA (0.36) CYP2C19MAOAMAOBCDK2MAPK1
SCHEMBL24920379 0.83 CDK2 (0.36) CYP2C19CYP1A2MAP4K1ALDH1A1CCNA2
SCHEMBL24922037 0.83 HRH4 (0.40) KDM4EHPGDCCNA2CDK2MAPK1
SCHEMBL24922047 0.83 CYP3A4 (0.34) CYP2C19CYP1A2MAP4K1MAOAMAOB
SCHEMBL24922030 0.83 CHRNB2 (0.40) CYP2C19MAOAMAOBMAPK1
SCHEMBL24922025 0.82 MAPK1 (0.35) CYP2C19MAOAMAOBKDM4EMEN1
SCHEMBL24920390 0.80 CHIA (0.40) PARP1KDM4ECCNA2CDK2MAPK1
SCHEMBL26626951 0.76 CYP2C19 (0.47) CYP2C19MAOAMAOBKDM4EMEN1
SCHEMBL12706720 0.75 CYP2C19 (0.43) CYP2C19CYP1A2CYP2C9KDM4EMEN1
SCHEMBL12969033 0.74 MAOA (0.41) CYP2C19CYP2C9MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023006097-A1 BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER 海创药业股份有限公司 2023-02-02 WO disclosed