Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24921761 | 0.81 | HDAC3 (0.46) | POLBTSHRCYP1A2KDM4EALDH1A1 | |
| SCHEMBL10272665 | 0.81 | POLB (0.53) | POLBAOC3TSHRCYP1A2MAPK1 | |
| SCHEMBL18885167 | 0.80 | CYP11B1 (0.56) | POLBAOC3CYP1A2SMN1; SMN2KDM4E | |
| SCHEMBL24437753 | 0.79 | GPR119 (0.51) | AOC3KDM4EALDH1A1GPR119HPGD | |
| SCHEMBL21791392 | 0.78 | GPR119 (0.45) | AOC3KDM4EALDH1A1GPR119KMT2A | |
| SCHEMBL24921466 | 0.77 | POLB (0.53) | POLBTSHRCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL29203454 | 0.77 | POLB (0.53) | POLBAOC3TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL568265 | 0.77 | POLB (0.53) | POLBAOC3TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL8191281 | 0.77 | POLB (0.57) | POLBAOC3TSHRMAPK1KDM4E | |
| SCHEMBL27086563 | 0.76 | GPR119 (0.47) | AOC3KDM4EGPR119KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |