Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24921172 | 0.77 | CCR1 (0.59) | PTGDRCCR1CCR5CCR8MAPK14 | |
| SCHEMBL14031549 | 0.75 | PDPK1 (0.40) | PIM1PIM2PDPK1BRD4MAPK9 | |
| SCHEMBL24920772 | 0.74 | NOTUM (0.45) | PIM1PIM2PDPK1CCR1CCR5 | |
| SCHEMBL24920894 | 0.74 | ACHE (0.40) | PTGDRPDPK1CCR1CCR5CCR8 | |
| SCHEMBL24921979 | 0.73 | PTGDR (0.39) | PTGDRBRD4NOTUMNPC1RAB9A | |
| SCHEMBL24921468 | 0.72 | PTGDR (0.36) | PTGDRBRD4MAPK14NOTUMNPC1 | |
| SCHEMBL24920898 | 0.72 | PDPK1 (0.39) | PIM1PIM2PDPK1MAPK9MAPK10 | |
| SCHEMBL24921174 | 0.72 | PIM1 (0.43) | PTGDRPIM1PIM2BRD4 | |
| SCHEMBL17253104 | 0.72 | PDPK1 (0.39) | PIM1PIM2PDPK1CCR1CCR5 | |
| SCHEMBL24920805 | 0.71 | KDM4E (0.43) | PIM1PDPK1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |