Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.61 |
| ▸ | MTR | Q99707 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | IL1B | P01584 | 1/20 | 0.39 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24592273 | 1.00 | CRBN (0.61) | CRBNMTRKMT2ACSNK1A1KDM5A | |
| SCHEMBL26318531 | 0.83 | CRBN (0.66) | CRBN | |
| SCHEMBL24817721 | 0.83 | CRBN (0.66) | CRBNCSNK1A1DDB1IKZF3 | |
| SCHEMBL25123189 | 0.82 | CRBN (0.65) | CRBNDDB1 | |
| SCHEMBL24046600 | 0.82 | CRBN (0.65) | CRBNCSNK1A1BRD4TNFIL1B | |
| SCHEMBL25513494 | 0.81 | CRBN (0.65) | CRBNCSNK1A1BRD4TNFIL1B | |
| SCHEMBL24592089 | 0.79 | CRBN (0.55) | CRBNTNFIL1BIKZF1DDB1 | |
| SCHEMBL24637351 | 0.79 | CRBN (0.50) | CRBNCSNK1A1BRD4TNFIL1B | |
| SCHEMBL24289013 | 0.79 | CRBN (0.49) | CRBNKMT2AHTR2CHTR2BPARP1 | |
| SCHEMBL24830140 | 0.79 | CRBN (0.50) | CRBNCSNK1A1BRD4TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |