Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3339728 | 0.86 | NPC1 (0.41) | L3MBTL1NPC1RAB9ALMNAHTT | |
| SCHEMBL3340545 | 0.86 | NPC1 (0.41) | L3MBTL1NPC1RAB9ALMNAHTT | |
| SCHEMBL3343006 | 0.86 | NPC1 (0.40) | L3MBTL1NPC1RAB9ALMNAHTT | |
| SCHEMBL3343752 | 0.83 | NPC1 (0.38) | L3MBTL1NPC1RAB9ALMNAHTT | |
| SCHEMBL3340388 | 0.83 | NPC1 (0.38) | L3MBTL1NPC1RAB9ALMNAHTT | |
| SCHEMBL12009834 | 0.83 | GRIN1 (0.40) | L3MBTL1NPC1RAB9ALMNAHTT | |
| SCHEMBL2492377 | 0.71 | NOTUM (0.46) | LMNA | |
| SCHEMBL22322658 | 0.71 | KMT2A (0.44) | L3MBTL1NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL25271059 | 0.70 | ALDH1A1 (0.47) | L3MBTL1LMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12011148 | 0.69 | MAPT (0.33) | LMNAALDH1A1KDM4ECYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324198-B1 | Monocarbams | PFIZER INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324198-B1 | Monocarbams | PFIZER INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324198-B1 | Monocarbams | PFIZER INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20120289455-A1 | Monocarbams | PFIZER INC. | 2012-11-15 | — | — | US | disclosed |
| US-20120289455-A1 | Monocarbams | PFIZER INC. | 2012-11-15 | — | — | US | disclosed |
| US-20120289455-A1 | Monocarbams | PFIZER INC. | 2012-11-15 | — | — | US | disclosed |
| US-8252782-B2 | Monocarbams | PFIZER INC. (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252782-B2 | Monocarbams | PFIZER INC. (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252782-B2 | Monocarbams | PFIZER INC. (US) | 2012-08-28 | — | — | US | disclosed |
| EP-2379546-A1 | MONOCARBAMS | Pfizer Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010070523-A1 | MONOCARBAMS | PFIZER INC. (US) | 2010-06-24 | — | — | WO | disclosed |
| US-20100160281-A1 | MONOCARBAMS | PFIZER INC | 2010-06-24 | — | — | US | disclosed |
| US-20100160281-A1 | MONOCARBAMS | PFIZER INC | 2010-06-24 | — | — | US | disclosed |
| US-20100160281-A1 | MONOCARBAMS | PFIZER INC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289455-A1 | Monocarbams | MRPL21, C1R, C5AR1 | L3MBTL1 2231/4885NPC1 1275/4885RAB9A 2420/4885 |
| US-20100160281-A1 | MONOCARBAMS | MRPL21, C1R, C5AR1 | L3MBTL1 2231/4885NPC1 1275/4885RAB9A 2420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.