Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6748172 | 0.79 | BRD4 (0.56) | NOTUM | |
| SCHEMBL24548630 | 0.76 | NOTUM (0.50) | NOTUMLMNA | |
| SCHEMBL7301708 | 0.74 | NOTUM (0.62) | NOTUM | |
| SCHEMBL7454214 | 0.73 | NOTUM (0.64) | NOTUM | |
| SCHEMBL29717244 | 0.72 | NOTUM (0.49) | NOTUM | |
| SCHEMBL2492380 | 0.71 | L3MBTL1 (0.45) | LMNA | |
| SCHEMBL14124897 | 0.71 | P4HTM (0.44) | — | |
| SCHEMBL3343006 | 0.69 | NPC1 (0.40) | LMNA | |
| SCHEMBL14124883 | 0.69 | XDH (0.56) | — | |
| SCHEMBL14124832 | 0.68 | MAP4K4 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324198-B1 | Monocarbams | PFIZER INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324198-B1 | Monocarbams | PFIZER INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324198-B1 | Monocarbams | PFIZER INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20120289455-A1 | Monocarbams | PFIZER INC. | 2012-11-15 | — | — | US | disclosed |
| US-20120289455-A1 | Monocarbams | PFIZER INC. | 2012-11-15 | — | — | US | disclosed |
| US-20120289455-A1 | Monocarbams | PFIZER INC. | 2012-11-15 | — | — | US | disclosed |
| US-8252782-B2 | Monocarbams | PFIZER INC. (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252782-B2 | Monocarbams | PFIZER INC. (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252782-B2 | Monocarbams | PFIZER INC. (US) | 2012-08-28 | — | — | US | disclosed |
| EP-2379546-A1 | MONOCARBAMS | Pfizer Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010070523-A1 | MONOCARBAMS | PFIZER INC. (US) | 2010-06-24 | — | — | WO | disclosed |
| US-20100160281-A1 | MONOCARBAMS | PFIZER INC | 2010-06-24 | — | — | US | disclosed |
| US-20100160281-A1 | MONOCARBAMS | PFIZER INC | 2010-06-24 | — | — | US | disclosed |
| US-20100160281-A1 | MONOCARBAMS | PFIZER INC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289455-A1 | Monocarbams | MRPL21, C1R, C5AR1 | NOTUM 2805/4885LMNA 3506/4885ELANE 999/4885 |
| US-20100160281-A1 | MONOCARBAMS | MRPL21, C1R, C5AR1 | NOTUM 2805/4885LMNA 3506/4885ELANE 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.