SCHEMBL2492490

SCHEMBL2492490

Cc1nc2nc(N)nc(O)c2nc1C

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.35
KDM4E B2RXH2 2/20 0.34
ALDH1A1 P00352 2/20 0.34
LMNA P02545 2/20 0.34
PIK3CG P48736 4/20 0.33
NQO2 P16083 1/20 0.31
PIK3CD O00329 1/20 0.30
PIK3C2B O00750 1/20 0.30
PDXK O00764 1/20 0.30
GAK O14976 1/20 0.30
MAP3K7 O43318 1/20 0.30
RIPK2 O43353 1/20 0.30
PIP5K1C O60331 1/20 0.30
STK16 O75716 1/20 0.30
PIK3C2G O75747 1/20 0.30
PRKD3 O94806 1/20 0.30
OXSR1 O95747 1/20 0.30
LATS1 O95835 1/20 0.30
ABL1 P00519 1/20 0.30
EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30570888 1.00 MAPT (0.35) MAPTKDM4EALDH1A1LMNAPIK3CG
SCHEMBL2494141 0.89 PIK3CG (0.33) MAPTPIK3CG
Leucopterin SCHEMBL968371 0.79 PIK3CG (0.36) MAPTPIK3CGPIK3CDPIK3C2BPDXK
SCHEMBL12787829 0.77 NQO2 (0.33) NQO2
SCHEMBL2493559 0.77 NQO2 (0.33) NQO2
SCHEMBL2492949 0.77 DHFR (0.46) MAPTKDM4EALDH1A1LMNAPIK3CG
SCHEMBL11185932 0.75 PIK3CG (0.46) MAPTKDM4EALDH1A1LMNAPIK3CG
SCHEMBL2175349 0.74 NQO2 (0.31) NQO2
SCHEMBL24726396 0.74 PIK3CG (0.49) MAPTKDM4EALDH1A1LMNAPIK3CG
SCHEMBL9681464 0.74 MAPT (0.35) MAPTKDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104807994-B Label-free thrombin detection method based on abasic sites 大连理工大学 2016-08-24 CN claimed
CN-109557764-B Chemically amplified positive photosensitive resin composition, resist pattern, method for forming the same, and electronic device 奇美实业股份有限公司 2023-09-12 CN disclosed
CN-104423170-B Photosensitive polysiloxane composition, protective film and assembly with protective film 奇美实业股份有限公司 2019-05-24 CN disclosed
CN-109557764-A Chemically amplified positive photosensitive resin composition, resist pattern and method for forming the same, and electronic device 奇美实业股份有限公司 2019-04-02 CN disclosed
CN-104807994-B Label-free thrombin detection method based on abasic sites 大连理工大学 2016-08-24 CN disclosed
US-9389509-B2 Photosensitive polysiloxane composition, protecting film and element having the protecting film CHI MEI CORPORATION (TW) 2016-07-12 US disclosed
US-20150346601-A1 PHOTOSENSITIVE POLYSILOXANE COMPOSITION, PROTECTIVE FILM AND ELEMENT HAVING THE PROTECTIVE FILM CHI MEI CORPORATION (TW) 2015-12-03 US disclosed
US-20150234275-A1 PHOTOSENSITIVE POLYSILOXANE COMPOSITION, PROTECTING FILM AND ELEMENT HAVING THE PROTECTING FILM CHI MEI CORPORATION (TW) 2015-08-20 US disclosed
CN-104849962-A Photosensitive polysiloxane composition, protective film and element with protective film CHI MEI CORP 2015-08-19 CN disclosed
CN-104807994-A Label-free thrombin detection method based on abasic sites UNIV DALIAN TECH 2015-07-29 CN disclosed
US-7541381-B2 Non-covalent inhibitors of AmpC β-lactamase NORTHWESTERN UNIVERSITY (US) 2009-06-02 US disclosed
US-7541381-B2 Non-covalent inhibitors of AmpC β-lactamase NORTHWESTERN UNIVERSITY (US) 2009-06-02 US disclosed
US-20070196827-A1 Method for detecting gene mutation and kit for detecting gene mutation JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2007-08-23 US disclosed
EP-1726663-A1 METHOD OF DETECTING GENE MUTATION AND KIT FOR DETECTING GENE MUTATION Japan Science and Technology Agency (JP) 2006-11-29 EP disclosed
US-7071376-B2 Genes encoding p-coumarate 3-hydroxylase (C3H) and methods of use PURDUE RESEARCH FOUNDATION (US) 2006-07-04 US disclosed
US-20020062496-A1 Genes encoding p-coumarate 3-hydroxylase (C3H) and methods of use PURDUE RESEARCH FOUNDATION 2002-05-23 US disclosed
WO-2002014497-A2 GENES ENCODING MUTANT P-COUMARATE 3-HYDROXYLASE (C3H) AND METHODS OF USE PURDUE RESEARCH FOUNDATION (US) 2002-02-21 WO disclosed
EP-0290819-B1 Pteridines suitable for the preparation of pharmaceutical compositions with antiamnesic activity BIORESEARCH SPA (IT) 1993-12-01 EP disclosed
US-5047405-A Alzheimer*s disease BIORESEARCH S.P.A. (IT) 1991-09-10 US disclosed
EP-0290819-A2 Pteridines suitable for the preparation of pharmaceutical compositions with antiamnesic activity BIORESEARCH S.p.A. (IT) 1988-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070196827-A1 Method for detecting gene mutation and kit for detecting gene mutation MSH2, KIT, STRADA MAPT 4582/4885KDM4E 4556/4885ALDH1A1 1651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.