Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11185932 | 0.83 | PIK3CG (0.46) | DHFRPIK3CGMAPTMEN1BLM | |
| SCHEMBL6824598 | 0.83 | DHFR (0.41) | DHFRPIK3CGMAPTMEN1BLM | |
| SCHEMBL9313963 | 0.83 | DHFR (0.41) | DHFRPIK3CGMAPTMEN1BLM | |
| SCHEMBL9237679 | 0.82 | ADORA2A (0.54) | DHFRPIK3CGMAPTMEN1BLM | |
| Bromide SCHEMBL5860793 | 0.81 | PIK3CG (0.40) | DHFRPIK3CGMAPTMEN1BLM | |
| Hydrochloric Acid SCHEMBL11291443 | 0.81 | PIK3CG (0.40) | DHFRPIK3CGMAPTMEN1BLM | |
| SCHEMBL3291956 | 0.79 | ADORA2A (0.52) | DHFRPIK3CGMAPTMEN1BLM | |
| SCHEMBL12261745 | 0.77 | MAPT (0.31) | MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL12577476 | 0.77 | DHFR (0.43) | DHFRPIK3CGMAPTMEN1BLM | |
| SCHEMBL2492490 | 0.77 | MAPT (0.35) | PIK3CGMAPTMTORKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4425346-A | ANTIGLAUCOMA AGENTS | SMITH AND NEPHEW ASSOCIATED COMPANIES LIMITED (GB) | 1984-01-10 | — | — | US | claimed |
| EP-0059524-A1 | Pharmaceutical composition containing aminopteridines or aminopyrimido(4,5-d)pyrimidines | Smith and Nephew Associated Companies p.l.c. (GB) | 1982-09-08 | — | — | EP | claimed |
| US-8330039-B2 | Solar cell modules with poly(vinyl butyral) encapsulant comprising unsaturated heterocyclic compound | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-11 | — | — | US | disclosed |
| EP-2380208-A1 | SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND | E. I. du Pont de Nemours and Company (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010085664-A1 | SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-07-29 | — | — | WO | disclosed |
| US-20100180947-A1 | SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-07-22 | — | — | US | disclosed |
| EP-0290819-B1 | Pteridines suitable for the preparation of pharmaceutical compositions with antiamnesic activity | BIORESEARCH SPA (IT) | 1993-12-01 | — | — | EP | disclosed |
| US-5047405-A | Alzheimer*s disease | BIORESEARCH S.P.A. (IT) | 1991-09-10 | — | — | US | disclosed |
| EP-0290819-A2 | Pteridines suitable for the preparation of pharmaceutical compositions with antiamnesic activity | BIORESEARCH S.p.A. (IT) | 1988-11-17 | — | — | EP | disclosed |
| US-4425346-A | ANTIGLAUCOMA AGENTS | SMITH AND NEPHEW ASSOCIATED COMPANIES LIMITED (GB) | 1984-01-10 | — | — | US | disclosed |
| EP-0059524-A1 | Pharmaceutical composition containing aminopteridines or aminopyrimido(4,5-d)pyrimidines | Smith and Nephew Associated Companies p.l.c. (GB) | 1982-09-08 | — | — | EP | disclosed |