Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22026727 | 0.82 | NFKB1 (0.68) | MAOBNFKB1MAOA | |
| SCHEMBL8402490 | 0.81 | NFKB1 (0.56) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL818741 | 0.81 | NFKB1 (0.56) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL5432209 | 0.80 | MAOB (0.45) | HDAC8HDAC6HDAC1MAOBNFKB1 | |
| SCHEMBL30071985 | 0.80 | MAOB (0.45) | HDAC8HDAC6HDAC1MAOBNFKB1 | |
| SCHEMBL5432212 | 0.80 | MAOB (0.45) | HDAC8HDAC6HDAC1MAOBNFKB1 | |
| SCHEMBL8529144 | 0.79 | NFKB1 (0.50) | MAOBNFKB1MAOA | |
| SCHEMBL9788936 | 0.79 | NFKB1 (0.50) | MAOBNFKB1MAOA | |
| SCHEMBL12425748 | 0.77 | HDAC8 (0.64) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL14244407 | 0.77 | HDAC8 (0.64) | HDAC8HDAC6HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230022696-A1 | SMALL MOLECULE INHIBITORS OF AUTOPHAGY AND HISTONE DEACTYLASES AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230022696-A1 | SMALL MOLECULE INHIBITORS OF AUTOPHAGY AND HISTONE DEACTYLASES AND USES THEREOF | HDAC5, HDAC4, HDAC7 | HDAC8 10/4885HDAC6 6/4885HDAC1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.