Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | FASN | P49327 | 2/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30361451 | 1.00 | HPGD (0.52) | HPGDNOS1NOS2KCNH2RXRA | |
| SCHEMBL24929885 | 0.89 | HPGD (0.51) | HPGDADORA2AFASNDDR1 | |
| SCHEMBL30361470 | 0.87 | HPGD (0.47) | HPGDNOS1NOS2KCNH2RXRA | |
| SCHEMBL24929303 | 0.87 | HPGD (0.47) | HPGDNOS1NOS2KCNH2RXRA | |
| SCHEMBL30947683 | 0.84 | HPGD (0.50) | HPGDKCNH2RXRAVNN1ADORA2A | |
| SCHEMBL24463691 | 0.83 | HPGD (0.53) | HPGDRXRAVNN1ADORA2ALRRK2 | |
| SCHEMBL30361471 | 0.82 | HPGD (0.52) | HPGDRXRAVNN1ADORA2ALRRK2 | |
| SCHEMBL24928925 | 0.82 | HPGD (0.47) | HPGDKCNH2RXRAVNN1ADORA2A | |
| SCHEMBL30361427 | 0.82 | HPGD (0.47) | HPGDKCNH2RXRAVNN1ADORA2A | |
| SCHEMBL24928921 | 0.81 | RXRA (0.47) | RXRAPDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009618-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO, INC. (US) | 2023-02-02 | — | — | WO | disclosed |