Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | EP300 | Q09472 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19728677 | 0.94 | ALDH1A1 (0.48) | DEGS1SMN1; SMN2KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL27211351 | 0.89 | DEGS1 (0.50) | DEGS1SMN1; SMN2KDM4EGLAHTT | |
| SCHEMBL27211422 | 0.88 | DEGS1 (0.52) | DEGS1SMN1; SMN2KDM4EGLAHTT | |
| SCHEMBL25344604 | 0.86 | DEGS1 (0.47) | DEGS1SMN1; SMN2KDM4EGLAHTT | |
| SCHEMBL27211406 | 0.83 | EP300 (0.45) | DEGS1SMN1; SMN2KDM4EGLAHTT | |
| SCHEMBL24931468 | 0.80 | ALDH1A1 (0.50) | DEGS1SMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL23207677 | 0.79 | DEGS1 (0.58) | DEGS1SMN1; SMN2KDM4EGLAHTT | |
| SCHEMBL15718927 | 0.79 | KDM4E (0.54) | DEGS1SMN1; SMN2KDM4EGLAHTT | |
| SCHEMBL29739499 | 0.78 | DEGS1 (0.50) | DEGS1SMN1; SMN2KDM4EGLAHTT | |
| SCHEMBL23166333 | 0.78 | KDM4E (0.57) | DEGS1SMN1; SMN2KDM4EGLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901280-B | MrgprX2 antagonists and uses thereof | 德米拉公司 | 2025-05-27 | — | — | CN | disclosed |
| US-20230027929-A1 | MrgprX2 Antagonists and Uses Thereof | DERMIRA, INC. | 2023-01-26 | — | — | US | disclosed |
| CN-114901280-A | MrgprX2 antagonists and uses thereof | 德米拉公司 | 2022-08-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230027929-A1 | MrgprX2 Antagonists and Uses Thereof | MRGPRX2, MRGPRX1, MRGPRX4 | DEGS1 1561/4885SMN1; SMN2 4122/4885KDM4E 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.