Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.36 |
| ▸ | GYS1 | P13807 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30240758 | 1.00 | PARP10 (0.39) | PARP10PARP15PARP14MAPK10GYS1 | |
| SCHEMBL24933386 | 0.85 | CDC7 (0.38) | PARP10PARP15PARP14GYS1HSD17B1 | |
| SCHEMBL24933375 | 0.84 | GRM2 (0.41) | PARP10PARP15HSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL24933501 | 0.83 | PARP10 (0.40) | PARP10PARP15PARP14GYS1MAPK8 | |
| SCHEMBL30240661 | 0.83 | PARP10 (0.40) | PARP10PARP15PARP14GYS1MAPK8 | |
| SCHEMBL30240731 | 0.82 | PARP10 (0.41) | PARP10PARP15PARP14GYS1HSD17B1 | |
| SCHEMBL24933028 | 0.82 | PARP10 (0.41) | PARP10PARP15PARP14GYS1HSD17B1 | |
| SCHEMBL30240673 | 0.81 | PARP10 (0.39) | PARP10PARP15PARP14GYS1FFAR4 | |
| SCHEMBL24933799 | 0.81 | PARP10 (0.39) | PARP10PARP15PARP14GYS1FFAR4 | |
| SCHEMBL24933637 | 0.81 | MAOB (0.44) | PARP10ALDH1A1MAPTBLMGPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |