Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 4/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.45 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852171 | 0.88 | PDK1 (0.51) | EPHA2PDK1ERBB2EPHB4P2RX3 | |
| SCHEMBL13984639 | 0.87 | EPHA2 (0.50) | EPHA2PDK1ERBB2EPHB4P2RX3 | |
| SCHEMBL1848811 | 0.87 | EPHA2 (0.50) | EPHA2PDK1ERBB2EPHB4P2RX3 | |
| SCHEMBL12661155 | 0.86 | PDK1 (0.49) | EPHA2PDK1ERBB2EPHB4P2RX3 | |
| SCHEMBL31712327 | 0.85 | EPHX2 (0.52) | EPHA2PDK1ERBB2EPHB4P2RX3 | |
| SCHEMBL13984286 | 0.85 | PDK1 (0.48) | EPHA2PDK1ERBB2EPHB4P2RX3 | |
| SCHEMBL30915187 | 0.85 | EPHX2 (0.52) | EPHA2PDK1ERBB2EPHB4P2RX3 | |
| SCHEMBL24933231 | 0.85 | PDK1 (0.57) | EPHA2PDK1EPHX2DRD4HRH3 | |
| SCHEMBL21069485 | 0.85 | EPHA2 (0.52) | EPHA2PDK1ERBB2EPHB4P2RX3 | |
| SCHEMBL12661156 | 0.84 | EPHA2 (0.48) | EPHA2PDK1ERBB2EPHB4P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | disclosed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |