Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24933225 | 0.85 | EPHA2 (0.58) | PDK1DRD4HRH3EPHA2EPHX2 | |
| SCHEMBL29203399 | 0.81 | PDK1 (0.50) | PDK1DRD4HRH3EPHA2KDR | |
| SCHEMBL29066435 | 0.79 | PDK1 (0.72) | PDK1ALDH1A1DRD4HRH3LMNA | |
| SCHEMBL15300862 | 0.77 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL30678382 | 0.77 | HRH3 (0.63) | PDK1DRD4HRH3EPHA2KDR | |
| SCHEMBL5369233 | 0.75 | PDK1 (0.65) | PDK1EPHA2KDR | |
| SCHEMBL26784458 | 0.75 | PDK1 (0.65) | PDK1EPHA2KDR | |
| SCHEMBL23848164 | 0.74 | IRAK4 (0.40) | PDK1DRD4EPHA2KDR | |
| SCHEMBL23854599 | 0.74 | IRAK4 (0.40) | PDK1DRD4EPHA2KDR | |
| SCHEMBL24933239 | 0.73 | DRD4 (0.54) | DRD4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | disclosed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |