Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 7/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30240745 | 1.00 | HSD17B1 (0.40) | HSD17B1HSD17B2PARP10CDK5CDK5R1 | |
| SCHEMBL24932968 | 0.90 | GRM2 (0.40) | HSD17B1HSD17B2CDK5CDK5R1GRIN1 | |
| SCHEMBL30240665 | 0.90 | GRM2 (0.40) | HSD17B1HSD17B2CDK5CDK5R1GRIN1 | |
| SCHEMBL30240728 | 0.89 | PARP15 (0.39) | HSD17B1HSD17B2PARP10CDK5CDK5R1 | |
| SCHEMBL24933819 | 0.89 | PRKAB2 (0.40) | HSD17B1HSD17B2MAOBHDAC3PARP1 | |
| SCHEMBL30240770 | 0.89 | PRKAB2 (0.40) | HSD17B1HSD17B2MAOBHDAC3PARP1 | |
| SCHEMBL24933394 | 0.89 | PARP15 (0.39) | HSD17B1HSD17B2PARP10CDK5CDK5R1 | |
| SCHEMBL24933463 | 0.89 | HSD17B1 (0.41) | HSD17B1HSD17B2PARP10CDK5CDK5R1 | |
| SCHEMBL24933801 | 0.87 | CD274 (0.44) | — | |
| SCHEMBL30240687 | 0.86 | HSD17B1 (0.35) | HSD17B1HSD17B2CDK5CDK5R1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |