Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGAV | P06756 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6748749 | 0.90 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAHTTTGM2L3MBTL1 | |
| Benzyl Phenethylcarbamate SCHEMBL4287199 | 0.80 | LMNA (0.73) | SMN1; SMN2LMNAHTTTGM2L3MBTL1 | |
| SCHEMBL6561678 | 0.78 | LMNA (0.46) | SMN1; SMN2LMNAHTTTGM2L3MBTL1 | |
| SCHEMBL13055383 | 0.78 | LMNA (0.80) | SMN1; SMN2LMNAHTTTGM2L3MBTL1 | |
| SCHEMBL6561674 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAHTTTGM2L3MBTL1 | |
| SCHEMBL12809389 | 0.76 | NR4A2 (0.48) | SMN1; SMN2LMNAHTTMEN1KMT2A | |
| Benzyl Phenethylcarbamate SCHEMBL6392045 | 0.76 | LMNA (0.67) | SMN1; SMN2LMNAHTTTGM2L3MBTL1 | |
| SCHEMBL10885850 | 0.76 | HTT (0.68) | SMN1; SMN2LMNAHTTTGM2L3MBTL1 | |
| SCHEMBL8848753 | 0.75 | LMNA (0.71) | SMN1; SMN2LMNAHTTTGM2L3MBTL1 | |
| SCHEMBL8802503 | 0.75 | LMNA (0.61) | SMN1; SMN2LMNAHTTTGM2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379513-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078408-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2010-07-08 | — | — | WO | disclosed |