Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30240659 | 1.00 | MRGPRX4 (0.49) | MRGPRX4NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL24932976 | 0.91 | MAOB (0.52) | MRGPRX4NPC1RAB9ASMN1; SMN2MAOB | |
| SCHEMBL30240782 | 0.91 | MAOB (0.52) | MRGPRX4NPC1RAB9ASMN1; SMN2MAOB | |
| SCHEMBL24933210 | 0.90 | MAOB (0.47) | MRGPRX4ALDH1A1MAOBHTTMAPT | |
| SCHEMBL24932919 | 0.88 | GYS1 (0.45) | MRGPRX4NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL30240739 | 0.88 | GYS1 (0.45) | MRGPRX4NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL24933199 | 0.85 | MAOB (0.46) | MRGPRX4NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL30240807 | 0.85 | MAOB (0.46) | MRGPRX4NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL24933615 | 0.85 | MAOB (0.60) | MRGPRX4MAOBHTTMAPTNR4A2 | |
| SCHEMBL24933362 | 0.85 | MAOB (0.47) | MRGPRX4MAOBHTTMAPTPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |