Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30240777 | 1.00 | PDE10A (0.39) | PDE10ADHODHALOX5APMAP4K4CNR1 | |
| SCHEMBL24933808 | 0.87 | PDE10A (0.39) | PDE10ADHODHALOX5APCNR1CNR2 | |
| SCHEMBL24933841 | 0.86 | HDAC1 (0.36) | PDE10ADHODHCNR1HDAC1HDAC6 | |
| SCHEMBL24933807 | 0.85 | ALOX5AP (0.36) | DHODHALOX5APCNR1HDAC1HDAC6 | |
| SCHEMBL30240750 | 0.85 | ALOX5AP (0.36) | DHODHALOX5APCNR1HDAC1HDAC6 | |
| SCHEMBL30240779 | 0.85 | PARP10 (0.51) | PDE10ADHODH | |
| SCHEMBL24933620 | 0.85 | PARP10 (0.51) | PDE10ADHODH | |
| SCHEMBL30240770 | 0.84 | PRKAB2 (0.40) | CNR1HDAC1HDAC6HDAC5 | |
| SCHEMBL24933819 | 0.84 | PRKAB2 (0.40) | CNR1HDAC1HDAC6HDAC5 | |
| SCHEMBL24933845 | 0.84 | SYK (0.42) | PDE10ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |