Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.37 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24934067 | 0.78 | MEN1 (0.43) | MAPTALDH1A1MEN1KMT2ATHRA | |
| SCHEMBL22890823 | 0.72 | ERN1 (0.41) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL24934282 | 0.64 | ABL1 (0.37) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL24933547 | 0.64 | ALDH1A1 (0.37) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL1420765 | 0.63 | TP53 (0.67) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL1420764 | 0.63 | TP53 (0.67) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL18302433 | 0.62 | TP53 (0.65) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL10790549 | 0.62 | TSHR (0.68) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL38656427 | 0.62 | ALDH1A1 (0.68) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL27570821 | 0.62 | ALDH1A1 (0.68) | MAPTALDH1A1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |