Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24934261 | 0.86 | DDR2 (0.32) | ABL1KITMAPK14DDR2 | |
| SCHEMBL24934206 | 0.78 | ABL1 (0.39) | ABL1KITABCG2FGFR1MAPK14 | |
| SCHEMBL24933525 | 0.76 | RORC (0.33) | — | |
| SCHEMBL24934256 | 0.73 | PSEN1 (0.36) | MAPK14MAPTSMN1; SMN2GAAKMT2A | |
| SCHEMBL24934295 | 0.72 | ABCG2 (0.38) | ABCG2MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL22890823 | 0.70 | ERN1 (0.41) | MAPTSMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL29218170 | 0.69 | FGFR1 (0.53) | FGFR1MAPTSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL24934259 | 0.69 | ABCG2 (0.41) | ABL1KITABCG2DDR2MAPT | |
| SCHEMBL30163129 | 0.67 | RXRA (0.41) | ABL1KITABCG2PDE5AMAPT | |
| SCHEMBL24933448 | 0.66 | SMN1; SMN2 (0.59) | FGFR1SMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |