SCHEMBL2493658

SCHEMBL2493658

Nc1nc(N)nc(-c2ccc(F)cc2)n1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.61
NPC1 O15118 4/20 0.61
ADORA2A P29274 3/20 0.60
ADORA1 P30542 2/20 0.60
POLB P06746 1/20 0.60
ADORA3 P0DMS8 1/20 0.60
ADORA2B P29275 1/20 0.60
HRH4 Q9H3N8 1/20 0.56
KDM4E B2RXH2 1/20 0.52
IKBKB O14920 1/20 0.50
BRAF P15056 1/20 0.50
ALDH1A1 P00352 2/20 0.47
HPGD P15428 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
DPP4 P27487 1/20 0.46
ALOX5 P09917 1/20 0.45
DHFR P00374 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6977760 0.98 RAB9A (0.59) RAB9ANPC1ADORA2AADORA1POLB
SCHEMBL28880529 0.87 RAB9A (0.76) RAB9ANPC1ADORA2AADORA1POLB
SCHEMBL27774680 0.86 NPC1 (0.57) RAB9ANPC1ADORA2AADORA1POLB
SCHEMBL6017000 0.82 RAB9A (0.47) RAB9ANPC1ADORA2AADORA1POLB
SCHEMBL6310578 0.81 HSP90AA1 (0.70) RAB9ANPC1ADORA2AADORA1POLB
SCHEMBL3420215 0.80 RAB9A (0.67) RAB9ANPC1ADORA2AADORA1POLB
SCHEMBL23733877 0.79 BCL2L1 (0.48) RAB9ANPC1ADORA2AADORA1ADORA3
SCHEMBL17269527 0.79 BCL2L1 (0.48) RAB9ANPC1ADORA2AADORA1ADORA3
SCHEMBL31366845 0.79 SMN1; SMN2 (0.51) RAB9ANPC1ADORA2AADORA1POLB
SCHEMBL6982316 0.78 RAB9A (0.64) RAB9ANPC1ADORA2AADORA1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1820001-A Substituted heterocyclic diarylamine analogues NEUROGEN CORP (US) 2006-08-16 CN claimed
CN-113461660-B 2,4, 6-trisubstituted-1, 3, 5-s-triazine compound, preparation and application thereof 浙江大学 2022-08-02 CN disclosed
CN-113461660-A 2,4, 6-trisubstituted-1, 3, 5-s-triazine compound, preparation and application thereof 浙江大学 2021-10-01 CN disclosed
US-8330039-B2 Solar cell modules with poly(vinyl butyral) encapsulant comprising unsaturated heterocyclic compound E I DU PONT DE NEMOURS AND COMPANY (US) 2012-12-11 US disclosed
EP-2380208-A1 SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND E. I. du Pont de Nemours and Company (US) 2011-10-26 EP disclosed
WO-2010085664-A1 SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-07-29 WO disclosed
US-20100180947-A1 SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-07-22 US disclosed
CN-1820001-A Substituted heterocyclic diarylamine analogues NEUROGEN CORP (US) 2006-08-16 CN disclosed
EP-0563386-A1 ANTICANCER COMPOSITION AND COMPOUND NIPPON SHINYAKU COMPANY, LIMITED (JP) 1993-10-06 EP disclosed
US-4333933-A ANTIINFLAMMATORY, REACTING HALO BENZOGUANAMINE WITH NICOTINE ACID DERIVAGIVE NIPPON SHINYAKU CO., LTD. (JP) 1982-06-08 US disclosed