Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 14/20 | 0.75 |
| ▸ | PTGFR | P43088 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373278 | 0.86 | DHODH (0.74) | DHODHPTGFRPDE10ADHFRALKBH5 | |
| SCHEMBL17593966 | 0.84 | DHODH (0.71) | DHODHPTGFRAURKAAURKBKDR | |
| SCHEMBL5418381 | 0.78 | DHODH (0.73) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL17593932 | 0.78 | PTGFR (0.68) | DHODHPTGFRDHFRALKBH5 | |
| SCHEMBL2372767 | 0.76 | DHODH (0.56) | DHODH | |
| SCHEMBL5442128 | 0.75 | DHODH (0.72) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL17593896 | 0.75 | PTGFR (0.65) | DHODHPTGFRAURKAAURKBKDR | |
| SCHEMBL8349971 | 0.74 | ALDH1A1 (0.66) | DHODHPTGFRAURKAAURKBKDR | |
| SCHEMBL5908719 | 0.73 | DHODH (0.95) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL5793184 | 0.72 | DHODH (0.79) | DHODHPDE10ADHFRALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549872-A1 | TRPV4 ANTAGONISTS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119701-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |