Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13741291 | 0.80 | HRH3 (0.51) | HRH3MEN1KMT2A | |
| SCHEMBL20131146 | 0.79 | HRH3 (0.41) | HRH3MEN1KMT2ASIGMAR1 | |
| SCHEMBL16997002 | 0.79 | HRH3 (0.39) | HRH3 | |
| SCHEMBL23103224 | 0.78 | SIGMAR1 (0.33) | HRH3SIGMAR1 | |
| SCHEMBL20795828 | 0.78 | HRH3 (0.35) | HRH3KMT2ASIGMAR1 | |
| SCHEMBL23114312 | 0.74 | SIGMAR1 (0.33) | HRH3SIGMAR1 | |
| SCHEMBL12026488 | 0.73 | HRH3 (0.41) | HRH3 | |
| SCHEMBL22794630 | 0.72 | HRH3 (0.37) | HRH3 | |
| SCHEMBL29348172 | 0.72 | NPC1 (0.36) | HRH3SIGMAR1 | |
| SCHEMBL23435356 | 0.72 | HRH3 (0.39) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230013778-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | LUPIN LIMITED (IN) | 2023-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230013778-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | SOS1, RSU1, KSR1 | HRH3 2175/4885MEN1 31/4885KMT2A 4241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.