Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.38 |
| ▸ | EML4 | Q9HC35 | 10/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.36 |
| ▸ | RET | P07949 | 9/20 | 0.36 |
| ▸ | ROS1 | P08922 | 9/20 | 0.36 |
| ▸ | FLT3 | P36888 | 9/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205711 | 1.00 | BTK (0.38) | BTKEML4ALKRETROS1 | |
| SCHEMBL24943829 | 0.92 | BTK (0.39) | BTKEML4ALKRETROS1 | |
| SCHEMBL30205651 | 0.92 | BTK (0.39) | BTKEML4ALKRETROS1 | |
| SCHEMBL29173385 | 0.92 | BTK (0.38) | BTKFLT3JAK3LCKEGFR | |
| SCHEMBL30205698 | 0.88 | BTK (0.34) | BTKEML4ALKRETROS1 | |
| SCHEMBL24944206 | 0.88 | BTK (0.34) | BTKEML4ALKRETROS1 | |
| SCHEMBL24944782 | 0.87 | RET (0.49) | BTKEML4ALKRETROS1 | |
| SCHEMBL30205589 | 0.85 | IKBKE (0.46) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24943840 | 0.85 | IKBKE (0.46) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944777 | 0.85 | EML4 (0.39) | BTKEML4ALKRETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |