Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 5/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.33 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | ROS1 | P08922 | 2/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30801879 | 1.00 | IKBKE (0.35) | IKBKETBK1EML4ALKSYK | |
| Formic Acid SCHEMBL30206162 | 0.97 | IKBKE (0.33) | IKBKETBK1EML4ALKSYK | |
| SCHEMBL24944496 | 0.92 | LRRK2 (0.36) | IKBKETBK1ALKTLR8TLR7 | |
| SCHEMBL30206172 | 0.92 | LRRK2 (0.35) | SYKTLR8TLR7CCNCCDK8 | |
| Formic Acid SCHEMBL30205591 | 0.90 | LRRK2 (0.35) | ALKTLR8TLR7CCNCCDK8 | |
| SCHEMBL24944183 | 0.89 | SYK (0.44) | EML4ALKSYKCCNCCDK8 | |
| SCHEMBL24944979 | 0.89 | FLT3 (0.40) | EML4ALKSYKLRRK2CDK2 | |
| SCHEMBL30205579 | 0.89 | SYK (0.44) | EML4ALKSYKCCNCCDK8 | |
| SCHEMBL30205675 | 0.89 | FLT3 (0.40) | EML4ALKSYKLRRK2CDK2 | |
| SCHEMBL24944172 | 0.88 | TBK1 (0.39) | IKBKETBK1EML4ALKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |