Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 2/20 | 0.31 |
| ▸ | CDK8 | P49336 | 2/20 | 0.31 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | SMC2 | O95347 | 1/20 | 0.30 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.30 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL30205591 | 0.97 | LRRK2 (0.35) | LRRK2EGFRALKPDCD1CD274 | |
| SCHEMBL30206337 | 0.93 | LRRK2 (0.39) | LRRK2EGFRALKPDCD1CD274 | |
| SCHEMBL30801879 | 0.92 | IKBKE (0.35) | LRRK2ALKPDCD1CD274TLR8 | |
| SCHEMBL24944188 | 0.92 | IKBKE (0.35) | LRRK2ALKPDCD1CD274TLR8 | |
| SCHEMBL24944494 | 0.91 | LRRK2 (0.42) | LRRK2EGFRALKCCNCCDK8 | |
| Formic Acid SCHEMBL30206162 | 0.90 | IKBKE (0.33) | LRRK2ALKPDCD1CD274TLR8 | |
| SCHEMBL31577238 | 0.85 | LRRK2 (0.36) | LRRK2TLR8TLR7TTK | |
| SCHEMBL30206172 | 0.85 | LRRK2 (0.35) | LRRK2EGFRPDCD1CD274TLR8 | |
| SCHEMBL24944783 | 0.84 | LRRK2 (0.41) | LRRK2EGFRALKCCNCCDK8 | |
| SCHEMBL24944183 | 0.83 | SYK (0.44) | ALKCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |