Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 15/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 15/20 | 0.34 |
| ▸ | RET | P07949 | 6/20 | 0.34 |
| ▸ | ROS1 | P08922 | 6/20 | 0.34 |
| ▸ | FLT3 | P36888 | 6/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | CIT | O14578 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.32 |
| ▸ | STK16 | O75716 | 1/20 | 0.32 |
| ▸ | STK10 | O94804 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24944214 | 0.89 | EML4 (0.35) | EGFRSYKEML4ALKRET | |
| SCHEMBL30205577 | 0.86 | CCNC (0.39) | EGFRSYKEML4ALKRET | |
| SCHEMBL24944200 | 0.86 | CCNC (0.39) | EGFRSYKEML4ALKRET | |
| SCHEMBL24944481 | 0.83 | SYK (0.35) | EGFRSYKEML4ALKRET | |
| SCHEMBL30205581 | 0.83 | SYK (0.35) | EGFRSYKEML4ALKRET | |
| SCHEMBL30206095 | 0.82 | SYK (0.36) | SYKEML4ALK | |
| SCHEMBL24944451 | 0.82 | SYK (0.36) | SYKEML4ALK | |
| SCHEMBL30206104 | 0.82 | BTK (0.37) | EGFRSYKEML4ALKRET | |
| SCHEMBL24944415 | 0.82 | BTK (0.37) | EGFRSYKEML4ALKRET | |
| SCHEMBL24943844 | 0.81 | CAMK2D (0.41) | EGFREML4ALKAURKACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |