Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 5/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.39 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.36 |
| ▸ | INSR | P06213 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | ROS1 | P08922 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205517 | 1.00 | MAPK9 (0.48) | MAPK9MAPK10ZAP70MAPK8LRRK2 | |
| SCHEMBL29173445 | 0.92 | ZAP70 (0.43) | MAPK9MAPK10ZAP70MAPK8LRRK2 | |
| SCHEMBL24944156 | 0.92 | MAPK9 (0.40) | MAPK9MAPK10ZAP70MAPK8LRRK2 | |
| SCHEMBL24943795 | 0.91 | MAPK9 (0.44) | MAPK9MAPK10ZAP70MAPK8LRRK2 | |
| SCHEMBL24944969 | 0.91 | LRRK2 (0.51) | MAPK9MAPK10ZAP70MAPK8LRRK2 | |
| SCHEMBL24944442 | 0.89 | RET (0.37) | MAPK9MAPK10ZAP70MAPK8LRRK2 | |
| SCHEMBL24943791 | 0.89 | EML4 (0.48) | ALKEML4JAK3RETROS1 | |
| SCHEMBL24944783 | 0.88 | LRRK2 (0.41) | MAPK9MAPK10LRRK2ALKEML4 | |
| SCHEMBL24943794 | 0.88 | RET (0.38) | MAPK9MAPK10MAPK8LRRK2ALK | |
| SCHEMBL24944164 | 0.88 | RET (0.36) | MAPK9MAPK10MAPK8LRRK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |