Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL29173332 | 0.97 | LRRK2 (0.39) | LRRK2CCNCCDK8GRM2MAPK9 | |
| Formic Acid SCHEMBL30205467 | 0.97 | LRRK2 (0.39) | LRRK2CCNCCDK8GRM2MAPK9 | |
| SCHEMBL24944786 | 0.93 | IKBKE (0.38) | GRM2RETROS1FLT3EML4 | |
| SCHEMBL29173386 | 0.92 | LRRK2 (0.43) | LRRK2CCNCCDK8SYKJAK2 | |
| SCHEMBL30206109 | 0.92 | LRRK2 (0.43) | LRRK2CCNCCDK8SYKJAK2 | |
| SCHEMBL24944494 | 0.92 | LRRK2 (0.42) | LRRK2CCNCCDK8ALKSYK | |
| SCHEMBL24944993 | 0.90 | LRRK2 (0.40) | LRRK2CCNCCDK8GRM2ALK | |
| SCHEMBL24944183 | 0.89 | SYK (0.44) | CCNCCDK8FLT3EML4ALK | |
| SCHEMBL30205579 | 0.89 | SYK (0.44) | CCNCCDK8FLT3EML4ALK | |
| SCHEMBL24944784 | 0.88 | LRRK2 (0.36) | LRRK2CCNCCDK8GRM2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |