Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.36 |
| ▸ | EML4 | Q9HC35 | 8/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 3/20 | 0.35 |
| ▸ | ROS1 | P08922 | 3/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL29173306 | 0.97 | ABL1 (0.36) | ABL1BCRIKBKETBK1EML4 | |
| Formic Acid SCHEMBL30205502 | 0.97 | ABL1 (0.36) | ABL1BCRIKBKETBK1EML4 | |
| SCHEMBL29173374 | 0.92 | ABL1 (0.37) | ABL1BCREGFRAXLKDM4E | |
| SCHEMBL30206314 | 0.92 | ABL1 (0.37) | ABL1BCREGFRAXLKDM4E | |
| SCHEMBL24943840 | 0.90 | IKBKE (0.46) | IKBKETBK1EML4ALKAXL | |
| SCHEMBL30205589 | 0.90 | IKBKE (0.46) | IKBKETBK1EML4ALKAXL | |
| Formic Acid SCHEMBL30206367 | 0.87 | IKBKE (0.43) | IKBKETBK1EML4ALKAXL | |
| SCHEMBL24943812 | 0.84 | IKBKE (0.38) | IKBKETBK1EML4ALKRET | |
| SCHEMBL30205471 | 0.84 | IKBKE (0.38) | IKBKETBK1EML4ALKRET | |
| SCHEMBL24944172 | 0.84 | TBK1 (0.39) | IKBKETBK1EML4ALKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |