Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206314 | 1.00 | ABL1 (0.37) | ABL1BCRPLK1BUB1KDR | |
| SCHEMBL24944444 | 0.92 | ABL1 (0.37) | ABL1BCRKDREGFRAXL | |
| SCHEMBL30205942 | 0.90 | CDK2 (0.39) | ABL1AXLKDM4EGAASMN1; SMN2 | |
| Formic Acid SCHEMBL30205502 | 0.90 | ABL1 (0.36) | ABL1BCRKDREGFRAXL | |
| Formic Acid SCHEMBL29173306 | 0.90 | ABL1 (0.36) | ABL1BCRKDREGFRAXL | |
| SCHEMBL29173590 | 0.85 | CDK1 (0.35) | KDREGFRBRD4RET | |
| SCHEMBL31577228 | 0.84 | AXL (0.37) | ABL1BCRKDREGFRAXL | |
| SCHEMBL29173415 | 0.83 | CCNC (0.42) | EGFRSMN1; SMN2 | |
| SCHEMBL29173496 | 0.82 | EML4 (0.42) | EGFRBRD4 | |
| SCHEMBL29173326 | 0.82 | ALK (0.36) | EGFRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |